Journal of Pharmaceutical Care 2017. 5(1-2):11-15.

Effect of Selenium Supplementation on CRP Levels and Incidence of Delirium in Critically Ill Patients
Babak Alikiaii, Sarah Mousavi, Seyed Taghi Hashemi, Mehran Abdollahi


Selenium (Se) as an essential micronutrient with antioxidant and anti-inflammatory effects plays a primary role in human immune system and there are some evidences for its impact in reducing plasma levels of inflammatory factors on one hand and also their role in increased incidence of delirium on the other hand.
The aim of his study is evaluation of the effect selenium on CRP plasma levels and incidence of delirium.
Settings and Design:
In a clinical trial included 100 patients admitted to the ICU of the Al-Zahra hospital in Isfahan (50 patients in the selenium group and 50 patients in the control group).
Methods and Material:
The plasma levels of C-reactive protein and incidence of delirium examined within 5 days and then compared.
Statistical analysis used:
The collected data were analysed using SPSS ver.23 (version 23, SPSS Inc., Chicago, IL).
During 5 days of hospitalization, 16 patients in the selenium group and 26 patients in the control group developed delirium in this term statistically there was no significant differences between the two groups (P=0.068).
During 5 days of hospitalization, plasma levels of CRPin the selenium group (mean = 11.1±2.20) significantly, was significantly lower than plasma levels of activated protein C in control group (mean= 16.75±1.65) (P<0.0001).
Administering selenium lead to a decrease in plasma levels of CRP but administering selenium caused no significant changes in the incidence of delirium.




Selenium (Se); C-reactive protein ; Delirium

Full Text:



Barrett CW, Short SP, Williams CS. Selenoproteins and oxidative stress-induced inflammatory tumorigenesis in the gut. Cell Mol Life Sci 2016: 1-10.

Duntas LH, Benvenga S. Selenium: an element for life. Endocrine 2015; 48(3): 756-75.

Mehdi Y, Hornick J-L, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules. 2013;18(3):3292-311.

Steinbrenner H, Al-Quraishy S, Dkhil M, Wunderlich F, Sies H. Dietary selenium in adjuvant therapy of viral and bacterial infections. Adv Nutr 2015 ; 6(1): 73-82.

Huang Z, Rose AH, Hoffmann PR. The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal 2012; 16(7): 705-43.

Manzanares W, Biestro A, Torre MH, Galusso F, Facchin G, Hardy G. High-dose selenium reduces ventilator-associated pneumonia and illness severity in critically ill patients with systemic inflammation. Intensive Care Med 2011; 37(7): 1120-7.

Maehira F, Miyagi I, Eguchi Y. Selenium regulates transcription factor NF-κB activation during the acute phase reaction. Clin Chim Acta 2003; 334(1): 163-71.

Hála M. Pathophysiology of postoperative delirium: systemic inflammation as a response to surgical trauma causes diffuse microcirculatory impairment. Med Hypothese 2007; 68(1): 194-6.

Alagiakrishnan K, Wiens C. An approach to drug induced delirium in the elderly. Postgrad Med J 2004; 80(945): 388-93.

Capri M, Yani SL, Chattat R, Fortuna D, Bucci L, Lanzarini C, et al. Pre-Operative, High-IL-6 Blood Level is a Risk Factor of Post-Operative Delirium Onset in Old Patients. Front Endocrinol (Lausanne) 2013; 5: 173.

Cevenini E, Caruso C, Candore G, Capri M, Nuzzo D, Duro G, et al. Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches. Curr Pharm Des 2010; 16(6): 609-18.

Fulop T, Larbi A, Witkowski JM, McElhaney J, Loeb M, Mitnitski A, et al. Aging, frailty and age-related diseases. Biogerontology 2010; 11(5): 547-63.

Larsson J, Itenov TS, Bestle MH. Risk prediction models for mortality in patients with ventilator-associated pneumonia: A systematic review and meta-analysis. J Crit Care 2017; 37: 112-8.

Marino PL. Marino's the ICU Book: Lippincott Williams & Wilkins; 2013.

Scheurig A, Thorand B, Fischer B, Heier M, Koenig W. Association between the intake of vitamins and trace elements from supplements and C-reactive protein: results of the MONICA/KORA Augsburg study. Eur J Clin Nutr 2008; 62(1): 127-37.

Ford E, Liu S, Mannino DM, Giles W, Smith S. C-reactive protein concentration and concentrations of blood vitamins, carotenoids, and selenium among United States adults. Eur J Clin Nutr 2003; 57(9): 1157-63.

Serwin AB, Wasowicz W, Chodynicka B. Selenium supplementation, soluble tumor necrosis factor-α receptor type 1, and C-reactive protein during psoriasis therapy with narrowband ultraviolet B. Nutrition 2006; 22(9): 860-4.

Rocha‐Pereira P, Santos‐Silva A, Rebelo I, Figueiredo A, Quintanilha A, Teixeira F. The inflammatory response in mild and in severe psoriasis. Br J Dermatol 2004; 150(5): 917-28.

Maehira F, Luyo GA, Miyagi I, Oshiro M, Yamane N, Kuba M, et al. Alterations of serum selenium concentrations in the acute phase of pathological conditions. Clin Chim Acta 2002; 316(1): 137-46.

Koyanagi A, Kuffo D, Gresely L, Shenkin A, Cuevas L. Relationships between serum concentrations of C-reactive protein and micronutrients, in patients with tuberculosis. Ann Trop Med Parasitol 2004; 98(4): 391-9.

Alertsen AR, Aukrust A, Skaug O. Selenium concentrations in blood and serum from patients with mental diseases. Acta Psychiatr Scand 1986; 74(2): 217-9.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.