Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 4 1-2 2017 09 18 44 45 EN Vajiheh Aghamollaii Roozbeh Psychiatric Hospital, Neurology Clinic, Tehran University of Medical Sciences, Tehran, Iran Zahra Ghelich Khan Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Andisheh Maneshi Department of Clinical Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Padideh Ghaeli Faculty of Pharmacy and Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran 2016 09 20 2017 04 05 Cosmetic side effects are among important causes for non-compliance in patients on anti-epileptics. Telogen effluvium (TE) is one of the most encountered cosmetic adverse effects. This report presents three patients with seizure disorder who developed levetiracetam- induced TE. Levetiracetam was considered to be a proper option for the treatment of the presented cases and therefore was not changed to other anti-epileptics. To manage TE, it was decided to add zinc sulfate to the therapeutic levetiracetam regimen. All three patients reported improvement in their hair condition as well as in controlling their seizure. Levetiracetam has favorable safety and efficacy profiles. However; the hair loss caused by this medication is a major drawback. Zinc sulfate was decided to be added to the therapeutic levetiracetam regimen in order to manage TE. All three patients reported improvement in their hair condition. Zinc supplementation is suggested to be safe and cost effective when considering management of levetiracetam-induced TE. https://jpc.tums.ac.ir/index.php/jpc/article/view/100 https://jpc.tums.ac.ir/index.php/jpc/article/download/100/101