Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 5 1-2 2018 05 13 2 6 EN Fatemeh Naseri Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Nasser Vahdati-Mashhadian Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. AND Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Mohammad Reza Saberi Medical Chemistry Department, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Amir Hooshang Mohammadpour Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AND Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Sepideh Elyasi Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AND Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. 2017 10 10 2017 12 23 Introduction: Inappropriate use of antibiotic, leads to microbial resistance, nosocomial infections and increased hospital costs. Therefore, it is necessary to control and evaluate the use of these medications, especially broad-spectrum antibiotics. This study evaluated the pattern of meropenem utilization in Imam Reza hospital, Mashhad, Iran. Methods: First, a guideline for proper indications of meropenem was designed and finalized based on the clinical pharmacists and infectious disease specialist’s comments. One hundred patients were chosen randomly from different wards of the hospital and their data were recorded in predesigned questionnaires. Then, the pattern of meropenem consumption was analyzed according to the guideline. Results: This study was performed in 100 patients, including 48 women and 52 men. In 13 cases (13%), patients had no approved indication for meropenem. The initial regimens were changed in 6 cases (6%) based on culture results and in 73 cases (73%) relied on clinical response. In 64 cases (64%), administrated doses were compatible with prepared guideline. Renal dose adjustment was acceptable based on guideline only in 30% of patients with renal impairment (30 patients out of 100). Hyper-sensitivity reaction, one of the adverse reactions of meropenem, was seen in 1 patient (1%). Conclusion: According to the results, considerable errors occurred in meropenem administration and dosing. Therefore, it is necessary to design and implement a localized guideline for meropenem consumption in Imam Reza hospital of Mashhad, Iran. https://jpc.tums.ac.ir/index.php/jpc/article/view/176 https://jpc.tums.ac.ir/index.php/jpc/article/download/176/123