Tehran University of Medical Sciences
Journal of Pharmaceutical Care
2322-4630
5
3-4
2018
08
27
Levodopa-benserazide Interaction with Enteral Nutrition: A Case Report
79
80
EN
Foroud
Shahbazi
Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran. AND Department of Clinical Pharmacy, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Hasanali
Karimpour
Department of Clinical Pharmacy, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Elham
Hosseini
Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2017
10
27
2017
10
29
Levodopa is considered one of the most important medication for parkinson symptoms control, it also first line agent for elderly and patients who symptoms don’t control with other agents. However, it has several drug and nutrition interactions. A few case of levodopa enteral nutrition has been reported.
https://jpc.tums.ac.ir/index.php/jpc/article/view/178
https://jpc.tums.ac.ir/index.php/jpc/article/download/178/140
="accepted">
2015
10
10
Background: An increased oxidative stress in patients under treatment with high concentrations of oxygen (hyperoxia) is considered to be one of the major mechanisms of lung injury. Between different mediators, transition metal ions especially iron, by generation of very reactive free radicals play an important role in oxidative stress process. Disruption of normal iron hemostasis has been reported in hyperoxic conditions. So we hypothesized that chelation of iron can reduce hyperoxia- induced lung injury.
Methods: Mechanically ventilated patients, who received oxygen with FiO > 0.5 for at least 3 days, underwent bronchoscopy at baseline and 72 hours thereafter. Data from external control cases were collected prospectively to provide a comparative reference group.Iron and Iron-related proteins were measured in lavage fluid and plasma.
Results: In 24 patients and in comparison with the results of previous study, Iron concentration decreased significantly in lavage fluid (P<0.001). Reduction of ferritin was not significant in lavage fluid (P: 0.7).Transferrin decreased significantly in plasma (P: 0.01). Acute Physiology And Chronic Health Evaluation (APACHE) II (P: 0.006) score decreased significantly after 7 days of follow-up.
Conclusion: Deferasirox did not change Iron and Iron-related protein in hyperoxic condition and it just only could be considered along with other supportive measures for better toleration of oxygen therapy.
https://jpc.tums.ac.ir/index.php/jpc/article/view/21
https://jpc.tums.ac.ir/index.php/jpc/article/download/21/21