Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 7 1-2 2019 08 31 34 36 Atousa Hakamifard Department of Infectious Diseases, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Sarah Mousavi Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Tahereh Gholipour-Shahraki Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Mohaghegh Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2018 12 30 2019 01 15 Fluoroquinolones have many adverse effects include the gastrointestinal tract and the central nervous system, phototoxicity, and dermal toxicity. Levofloxacin has favorable adverse reaction profiles compared to other fluoroquinolones. Among the reported dermal toxicity there are few reports of toxic epidermal necrosis (TEN) in association with levofloxacin usage. However, there is no published study on levofloxacin induced stomatitis. Stomatitis is characterized by pain, infl ammation, and ulceration in the oral cavity. A 36-year-old man was referred to the hospital for ‘painful oral swelling and ulceration’. Before the admission due to fever and productive cough, 750 mg levofloxacin were prescribed for him. After 2 days of consumption, the patient experiences painful ulcerative and erythema lesions in the oral cavity that consistent with stomatitis. Due to the possibility of a drug reaction, levofloxacin was discontinued and no other antibiotic was used. Oral lesions were managed with a mouthwash and after 5 days, lesions recovered. To the best of our knowledge, this is the first case who developed stomatitis after two dose of levofl oxacin and recovered just with topical therapy and without any systemic treatment. Caution is advised while administering these drugs. https://jpc.tums.ac.ir/index.php/jpc/article/view/247