Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 7 1-2 2019 08 31 37 38 EN Ankitha peetha Doctor of Pharmacy, Nirmala College of Pharmacy, Mangalagiri-522503, Guntur, Andhra Pradesh, India Nahida Shaik Doctor of Pharmacy, Nirmala College of Pharmacy, Mangalagiri-522503, Guntur, Andhra Pradesh, India Spandana Ayela Doctor of Pharmacy, Nirmala College of Pharmacy, Mangalagiri-522503, Guntur, Andhra Pradesh, India 2019 02 19 2019 03 19 Myocardial infarction can be complicated by Ventricular septal rupture which is a rare fatal grim mechanical complication of MI which is a surgical emergency due to its incredibly high mortality rate. We depict a case of Anterior wall MI which was complicated by Ventricular septal rupture post fibrinolytic therapy. https://jpc.tums.ac.ir/index.php/jpc/article/view/251