Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 7 3 2019 12 28 49 53 Mandana Izadpanah Assistant Professor of Clinical Pharmacy, Department of Clinical Pharmacy, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Negin Amraie Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran Farhad Soltani Department of anesthesiology and critical care medicine faculty of medicine, ahvaz jundishapur university of medical sciences, Ahvaz, Iran Leila Kouti Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran university of medical sciences, Tehran, Iran Sepideh Sayyadi Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran Maryam Aghakouchakzadeh Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran university of medical sciences, Tehran, Iran Maryam Hariri Pharm.D, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran 2019 05 18 2019 11 10 Background: Oral medication administration through enteral feeding tubes is a challenging issue in critically ill patients, which can lead to medication error. Patients admitted to the intensive care unit may not have the ability to swallow oral medications for various reasons such as lack of consciousness, or the need for mechanical ventilation. Improving the quality of drug administration through enteral feeding tubes is essential. Objectives: The present study aimed at evaluation of the prevalence of medication errors that occur during the administration of oral medications through enteral feeding tubes in mechanically ventilated critically ill patients. Methods: This study was a cross-sectional observational study conducted in Golestan Educational Hospital, Ahvaz, Iran. Oral medication administration was evaluated in 50 patients within three months; information about each patient was examined. The errors were measured according to the Handbook of Drugs Administration via enteral feeding tubes. Results: Errors occurred in percentage of total prescriptions as follows: Drug-drug interaction 26%, wrong preparation 22.28%, wrong form 12.09%, wrong time 11.57%, drug-food interaction 6.73%, wrong dose 5.53%, wrong route 3.8%, extra dose 0.86%, omission 0.18%, deteriorated drug 0.18%, and unordered drug 0.0%. In our study, it was found that most of the drugs were administered in solid dosage forms, and almost 33% of them could be substituted for injection or oral liquid formulations. Conclusion: Our study indicated the high frequency of drug administration and preparation errors in mechanically ventilated critically ill patients. Close teamwork between pharmacists or pharmacotherapists, physicians, and nurses can result in the appropriate administration of medications by an enteral feeding tube.  https://jpc.tums.ac.ir/index.php/jpc/article/view/263