Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 7 4 2020 02 03 120 122 EN Nima Vaziri School of Pharmacy, Kerman University of Medical Science, Kerman, Iran. Habib Mofakham Neuromuscular research center, Department of physical medicine and rehabiliation, University of California, Davis Fanak Fahimi Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran. 2019 10 29 2020 01 13 The most reported form of statin induced pain is myalgia, conversely peripheral neuropathy is a rare side effect. We report a patient who received rosuvastatin for hypercholesterolemia and experienced episodes of pain in both hands during the night. Rosuvastatin was stopped and atorvastatin was replaced. Re-introduction with another statin resulted in a more severe form of the similar adverse effect after 4 months. This is a rare adverse effect of a extensively prescribed class of drug. Physicians should be aware of the possibility of peripheral neuropathy symptoms in patients on statin therapy. https://jpc.tums.ac.ir/index.php/jpc/article/view/294 https://jpc.tums.ac.ir/index.php/jpc/article/download/294/217