Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 1 1 2015 10 10 8 12 EN Ebrahim Salehifar Associate Professor of Clinical Pharmacy, Mazandaran University of Medical Sciences, Faculty of Pharmacy, Clinical Pharmacy Department, Pharmaceutical Research Center, Pharmaceutical Care Department of Emam Khomeini Hospital, Sari, Mazandaran, Iran Shahram Ala Associate Professor of Clinical Pharmacy, Mazandaran University of Medical Sciences, Faculty of Pharmacy, Clinical Pharmacy Department, Pharmaceutical Research Center, Pharmaceutical Care Department of Emam Khomeini Hospital, Sari, Mazandaran, Iran Mina Amini Pharmacist, Pharmaceutical Care Department of Emam Khomeini Hospital, Sari, Mazandaran, Iran Elham Azhdari Pharmacist, Pharmaceutical Care Department of Emam Khomeini Hospital, Sari, Mazandaran, Iran Farzaneh Mir-Shafa Pharmacist, Food and Drug Deputy of Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran 2015 10 10 2015 10 10 Background: Following establishment of Iranian Adverse Drug Reaction (ADR) Monitoring  Center  in  1997, ADR  committees  were  established  in  all  hospitals  of Mazandaran Province of Iran. Clinical pharmacists from Mazandaran University of Medical Sciences have been involved with these committees since 2007. The aim of this study was to compare the results of the pharmacovigilance system before and after active involvement of clinical pharmacists. Methods:  This  study  included Yellow  Cards  filled out  by  healthcare  providers  inMazandaran Province during 2004-2010. Frequency of Adverse Drug Reactions (ADRs), route of administration, reporters, number of reports in each years and damaged organs were focuses. Statistical analysis was performed by SPSS 16 software. P< 0.05 was considered as significant difference. Results: A total of 793 yellow cards were completed during 2004 – 2010. Only 38 ADRs(4.8%) were related to 2004-2007. Most of the reports generated by Nurses (49.3%) followed by Pharmacists and Physicians (P< 0.001). Forty-one reactions (5.2%) were serious, most related to Ceftriaxone, Desfonac and Vancomycin. Conclusion: Clinical pharmacists’ intervention regarding establishing ADR committees in the hospitals improved the output of the pharmacovigilance system, although under- reporting is still a major drawback of spontaneous reporting. https://jpc.tums.ac.ir/index.php/jpc/article/view/3 https://jpc.tums.ac.ir/index.php/jpc/article/download/3/3