Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 8 2 2020 06 26 90 92 EN Fatma Hammami Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia Makram Koubaa Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia Sahar Ben Kahla Cardiology Department, Hedi Chaker University Hospital, University of Sfax, Tunisia Amal Chakroun Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia Khaoula Rekik Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia Fatma Smaoui Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia Mounir Ben Jemaa Infectious Diseases Department, Hedi Chaker University Hospital, University of Sfax, Tunisia 2020 02 13 2020 03 01 Despite their adverse effects, fluoroquinolones continue to be commonly prescribed antibiotics. Ciprofloxacin remains the safest with remarkably few adverse effects of all fluoroquinolones. Here, we present a rare case of paroxysmal atrial fibrillation induced by ciprofloxacin intake in a 72-year-old woman. She was treated with ciprofloxacin and ceftriaxone for urinary tract infection caused by Klebsiella pneumonia and complicated with liver abscess. On the fifth day of ciprofloxacin intake, she suddenly complained of heart palpitations and epigastric pain. An electrocardiogram revealed supraventricular tachycardia type atrial fibrillation at 130 beats per minute. No QT interval prolongation was noted. Ciprofloxacin was stopped as it was the most incriminated to induce arrhythmia. A control electrocardiogram showed normal sinus rhythm. We continued ceftriaxone use solely for 3 weeks until the resolution of the liver abscess. Although rare, early detection of atrial fibrillation induced by ciprofloxacin may decrease the severity of complications and prevent death. https://jpc.tums.ac.ir/index.php/jpc/article/view/324