Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 8 3 2020 09 28 133 139 Samir Derouiche Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences, El-Oued University, El Oued 39000, El Oued, Algeria AND Laboratory of Biodiversity and Application of Biotechnology in the Agricultural Field, Faculty of Natural Sciences and Life, University of El Oued, El-Oued 39000, Algeria. Taissir Cheradid Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences, El-Oued University, El Oued 39000, El Oued, Algeria. Djoumana Abdelmalek Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences, El-Oued University, El Oued 39000, El Oued, Algeria. Ikram Achi Department of Cellular and Molecular Biology, Faculty of Natural and Life Sciences, El-Oued University, El Oued 39000, El Oued, Algeria. 2020 05 15 2020 06 19 Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. The pandemic outbreak of COVID-19 is rapidly spreading all over the world. This review aims to provide a relationship between the alteration of immune system during  COVID-19 infection and the risk of developing diabetes complications. The risk of COVID-19 infection in patients is due not only to the severity of the viral infection but also to the host's immune response. The risk of infection is one of the main complications of diabetics, as it has been suggested that diabetes inhibits the immune response which contributes to infection and progression to symptoms. also, The evidence of generation of oxygen free radicals and oxidative stress is a key process in the onset of diabetes mellitus which participate in the development of the systemic inflammatory response syndrome. In addition, chronic hyperglycemia during COVID-19 infection may increase the release of inflammatory cytokines, a high ability to bind to the virus ACE2 glycosylated, worsen the ketoacidosis and vascular complications that may explain the severity of the SARS-CoV-2 infection in diabetic patients. https://jpc.tums.ac.ir/index.php/jpc/article/view/350