Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 1 1 2015 10 10 13 18 EN Kheirollah Gholami Clinical Pharmacy Department, Faculty of Pharmacy and Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran Mohammadreza Rouini Department of Pharmaceutics, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Niayesh Mohebbi Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Iman Karimzadeh Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran Mehdi Ahadi-barzoki Food and Drug Administration, Ministry of Health, Tehran, Iran Mahboob Lessan-pezeshki Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran Saeed Rezaee Department of Pharmaceutics, Faculty of Pharmacy, Ahvaz University of Medical Sciences, Ahvaz, Iran 2015 10 10 2015 10 10 Background: The purpose of this study was to characterize the pharmacokinetic parameters of mycophenolic acid (MPA) in Iranian kidney transplant patients. Methods: Plasma MPA concentration of mycophenolate mofetile (MMF) 1 gram two times a day was measured in 21 Iranian kidney transplant recipients receiving treatment. Patients who entered the study had been transplanted for more than 3 months and their drug level was supposed to be at steady state. MMF concentration was measured with High- Performance Liquid Chromatography (HPLC). Results: The plasma MPA concentration-time curve was characterized by an early sharp peak at about 1 hour postdose. The mean Area Under Curve (AUC), Cmax and Tmax were 47.0±18.3 µg.h/ml, 18.6±8.5 µg/ml and 1.0±0.5 hours respectively. Conclusion: The plasma MPA concentration-time curve pattern of Iranian patients was similar and consistent with previously reported profiles in other populations taking the same dose. https://jpc.tums.ac.ir/index.php/jpc/article/view/4 https://jpc.tums.ac.ir/index.php/jpc/article/download/4/4