Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 10 3 2022 10 01 180 182 Neda Taner Department of Clinical Pharmacy, School of Pharmacy, İstanbul Medipol University, İstanbul,Turkey. Betül Şirin Department of Clinical Pharmacy, School of Pharmacy, İstanbul Medipol University, İstanbul,Turkey. Barış Taner Department of Orthopedics and Traumatology, Kolan Hospital, İstanbul,Turkey. 2022 05 31 2022 07 03 A fever above 38°C is a common complication in the first few days after major surgery. Drug-induced fever is the most common cause of fever among the noninfectious causes of postoperative fever. Antimicrobial drugs and heparin, widely used for venous thromboembolism prophylaxis after major orthopedic surgery, are the drugs most commonly associated with postoperative fever. This case study, showing that enoxaparin may be the drug responsible for unexplained fever, may help significantly reduce patient morbidity and the additional costs of investigating the underlying causes of fever. At this stage, the approaches of the clinical pharmacist to provide counseling services to the patient and the healthcare professional in the treatment of medications, the detection of side effects of medications and the suggestion of a solution are important. https://jpc.tums.ac.ir/index.php/jpc/article/view/502