Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 11 1 2023 04 24 40 53 AmirHosein Sanei School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Farshad Abedi Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Moeini Nodeh Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AmirHooshang Mohammadpour Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Abolghasem Allahyari Division of Hematology and Oncology, Department of Internal Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Fariba Zemorshidi Department of Neurology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Omid Arasteh Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran 2022 12 24 2023 02 25 Taxane-induced peripheral neuropathy (TIPN) is a dose-limiting adverse effect of chemotherapy without any specific treatment. The aim of this paper is to evaluate the effects of natural products and supplements on TIPN. PubMed, Google Scholar and Web of Science databases were searched through August 2022 regarding TIPN and effects of natural products and supplement therapy. Data consists of preclinical studies, randomized controlled trials and case reports. After screening of 230 papers, we found 13 relevant animal and human studies regarding possible benefits of vitamin E, glutamine, omega-3, acetyl-L-carnitine and group of B vitamins on TIPN. Results demonstrated that vitamin E can be helpful on prevention and duration of TIPN. Glutamine and B vitamins showed hopeful results on reducing pain sensation. Omega-3 also shows promising results on incidence of TIPN. However, acetyl-L-carnitine might develop and worsen neuropathy. Although some supplements revealed promising effects on prevention and treatment of TIPN, researches are still limited and we need further long-term large sample size trials to confirm clinical efficacy of these supplements. https://jpc.tums.ac.ir/index.php/jpc/article/view/553