Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 1 1 2015 10 10 25 28 EN AmirHooshang Mohammadpour School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AND Pharmaceutical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Seyed Adel Moallem School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran AND Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Bafandegan School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Jamal Shamsara School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Fatemeh Nazemian Nephrology Ward, Department of Internal Medicine, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran AND Vascular Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2015 10 10 2015 10 10 Background: It has been shown that serum total homocysteine (HC) is a risk factor for vascular disease which characterizes endothelial damage in the general and in the End-Stage Renal Disease (ESRD) population as well. Whether n-3 polyunsaturated fatty acids decrease homocysteine (Hcy) level has been a subject of controversy. Methods: Renal transplant patients were randomized in 2 groups and received 6 months of dietary supplementation with 6 g/day of Fish oil or placebo. Homocysteine level and total cholesterol level were measured. Results: In 40 renal transplant recipients, increase in homocysteine level was greater after Fish oil administration but not significantly, total cholesterol was decreased significantly. Conclusion: Based on these data omega3 fatty acids supplementation doesn’t decrease serum homocysteine in renal transplant recipients but decreases total cholesterol level. https://jpc.tums.ac.ir/index.php/jpc/article/view/6 https://jpc.tums.ac.ir/index.php/jpc/article/download/6/6