Tehran University of Medical Sciences Journal of Pharmaceutical Care 2322-4630 3 3-4 2017 03 15 79 81 EN Mahdi Bagheri Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mamak Tahmasebi Cancer Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Sheyda Najafi Cancer Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran. Zahra Jahangard Rafsanjani Department of Pharmacotherapy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 2016 04 30 2016 06 06 Gross hematuria or macroscopic hematuria is a high risk urologic condition that might occur in different settings. In the case of continued gross hematuria, blood clot size may grow and lead to complete obstruction of urinary outflow. Placement of three-way catheter, continuous bladder irrigation with normal saline, and cystoscopy are conventional treatments. Here we introduce a case with urinary obstruction who did not respond to conventional therapies. A subject of Hodgkin lymphoma with urinary obstruction caused by heavy gross hematuria was presented to emergency department. Three-way catheter was inserted to facilitate urination. However, there was no urinary drainage and bladder was distended. Consequently, 100 ml solution of hydrogen peroxide 0.15% was prepared and administered into the bladder to irrigate and evacuate the clots. A single intravesical infusion of hydrogen peroxide rapidly resolved urinary obstruction and improved patient distress. After administration of hydrogen peroxide solution, blood clots and bloody urine were evacuated successfully. These findings suggest that an intravesical injection of hydrogen peroxide can induce dissolution of blood clots and may be a simple and efficient therapy for urinary obstruction due to gross hematuria. https://jpc.tums.ac.ir/index.php/jpc/article/view/84 https://jpc.tums.ac.ir/index.php/jpc/article/download/84/88