Compliance with antimicrobial therapy: Evaluating the related factors

  • Mandana Moradi Assistant Professor of Clinical Pharmacy, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
  • Soudabeh Hamedi-Shahraki MSc in Statistics, Faculty of Health, Zabol University of Medical Sciences, Zabol, Iran
  • Mahdiyeh Rezayee Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
  • Mohsen Verdi Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran
Keywords: Anti-Bacterial Agents, Patient Compliance, Drug Resistance, Microbial

Abstract

Background: Uncontrolled and irrational use of antibiotics increases the rate of antimicrobial resistance and treatment failure. Compliance with antibiotics is an important indicator to show how patients use their prescribed drugs and it can explain the relationship between drug administration and treatment outcome that needs to be monitored and promoted. We decided to evaluate compliance to antimicrobial drugs in this study.
Methods: In a cross-sectional study, 100 patients referring to 4 different specialists’ offices were enrolled. The rate and type of non prescribed antibiotic administration were evaluated using predesigned questionnaires. The data were analyzed by SPSS 17.0 software using descriptive statistics and chi-square test for categorical data.
Results: Our results showed that 62.4% of the study population had poor compliance and 37.6 % had good compliance with their prescribed regimen. “Feeling better “and “getting worse” on prescribed regimen were major reasons for drug discontinuation. About 70% of our study population get non prescribed antibiotic from pharmacies at least once a year. Most of the requested antibiotics were not first line options. Level of education was the only factor significantly related to the rate of patient compliance.
Conclusion: This study shows the high rate of non prescribed
antibiotic administration and low rate of compliance among the study population that emerge the need for particular patient education and putting restrictive rules to bound  non-prescribed and unsupervised  antibiotic marketing.

References

Cals JW, Hopstaken RM, Le Doux PH, Driessen GA, Nelemans PJ, Dinant GJ. Dose timing and patient compliance with two antibiotic treatment regimens for lower respiratory tract infections in primary care. Int J Antimicrob Agents 2008; 31(6): 531-6.

Jin J, Sklar GE, Min Sen Oh V, Chuen Li S. Factors affecting therapeutic compliance: A review from the patient’s perspective. Ther Clin Risk Manag 2008; 4(1): 269–86.

Cramer JA. Microelectronic systems for monitoring and enhancing patient compliance with medication regimens. Drugs 1995; 49: 321–7.

Smith R, Coast J. Antimicrobial resistance: a global response. Bulletin of the World Health Organization 2002; 80:126-33.

Urquhart J. Ascertaining How much compliance is enough with outpatient antibiotic regimens. Postgrad Med J 1992; 68 Suppl 3: S49- 58;

Kardas P. Patient compliance with antibiotic treatment for respiratory tract infections. J Antimicrobi Chemother 2002; 49: 897-903.

Greenberg RN. Overview of patient compliance with medication dosing: a literature review. Clin Ther 1984; 6: 592-9.

Claxton AJ, Cramer J, Pierce C. A systematic review of the association between dose regimens and medication compliance. Clin Ther 2001; 23: 296-310.

Saifi M, Pourshafie MR, Eshraghian MR, Soltan Dallal MM. Anti- Microbial resistance of Enterococci isolated from Urinary Tract Infections in Iran. Iranian Biomed J 2008; 12(3):185-90.

Sirous M, Mehrabadi J, Daryani NE, Eshraghi S, Hajikhani S, Shirazi MH. Prevalence of antimicrobial resistance in Helicobacter pylori isolates from Iran. African Journal of Biotechnology 2010; 9(36): 5962-5.

Favre O, Delacrétaz E, Badan M, Glauser M, Waeber B. Relationship between the prescriber’s instructions and compliance with antibiotherapy in outpatients treated for an acute infections disease. J Clin Pharmacol 1997; 37: 175-8.

Carter BL, Foppe van Mil JW. Comparative Effectiveness Research: Evaluating Pharmacist Interventions and Strategies to Improve Medication Adherence. Am J Hypertens 2010; 23: 949-55. |

Wiedenmayer K, Summers R, Mackie C, Gous A, Everard M. Developing pharmacy practice: A focus on patient care. 2006 ed. Geneva: World Health Organization; 2006.

Cockburn J, Reid AL, Sanson-Fisher RW. The process and content of general – practice consultations that involve prescription of antibiotic agents. Med J Aust 1987; 14(7): 321-4.

Published
2015-10-10
How to Cite
1.
Moradi M, Hamedi-Shahraki S, Rezayee M, Verdi M. Compliance with antimicrobial therapy: Evaluating the related factors. J Pharm Care. 1(2):60-64.
Section
Original Article(s)