Journal of Pharmaceutical Care 2016. 4(4-3):75-78.

Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea
Parastoo Azimi, Ramin Abrishami


Background: In previous studies, extract of 3 herbs, celery, fenugreek and saffron was effective on primary dysmenorrhea. However, the health effects of saffron alone on primary dysmenorrhea have not been yet studied. The aim of this double blind, single center clinical trial is to examine the effects of saffron on primary dysmenorrhea pain in women aged 18-27 years old.
Methods: One hundred eighty patients were randomly divided into three groups. Group 1 received saffron capsules three times per day for three days of menstrual period for three consecutive menstrual cycles. Group 2 received mefenamic acid, and group 3 has received identical placebo. Visual Analogue Scale (VAS) has been recorded at baseline and after each menstrual period.
Results: In saffron group VAS was reduced from 6.8 to 3.6, 3.4, and 3 in 3 consecutive months. This effect was significantly greater than mefenamic acid and placebo (P:0.0001).
Conclusions: It was found that the effect of saffron in reducing pain is more than mefenamic acid and far more than placebo.



Crocus Sativus Mefenamic Acid Dysmenorrhea Visual Analog Scale

Full Text:



Khodakrami N, Moatar FA, Ghahiri A. The effect of an Iranian herbal drug on primary dysmenorrhoea-A clinical control trial. The Horizon of Medical Sciences. 2008 Jul 15;14(2):11-9.

Novak E. Berek & Novak's gynecology. Lippincott Williams & Wilkins; 2007.

Berkowitz RS, Barbieri RL, Dunaif AE, Ryan JD, Barbieri RL. Kistner's Gynecology and women's health. Mosby Inc. 1999:345-93.

Sadatian SA. Fundamental affectations of gynecology CMMD. Tehran: Nore Danesh Publication. 2004:33-5.

Ogilvie RA. Dysmenorrhoea. Journal of Complementary Medicine: CM, The. 2005 Mar;4(2):73.

Rapkin AJ, Gambone JC. Dysmenorrhea and chronic pelvic pain. Essential of obstetrics and gynecology]. 4th ed. Arian Mehr S, Mohamadi M.(translators). Tehran: Teymorzade-Tabib. 2005:290-1.

Nazarpour S. The study of correlation between body image and coping styles with severity of primary dysmenorrhea. Psychol Health Essentials J. 2011;14(7):344-55.

Burnett MA, Antao V, Black A, Feldman K, Grenville A, Lea R, Lefebvre G, Pinsonneault O, Robert M. Prevalence of primary dysmenorrhea in Canada. Journal of Obstetrics and Gynaecology Canada. 2005 Aug 1;27(8):765-70.

Mohamed EM. Epidemiology of dysmenorrhea among adolescent students in Assiut City, Egypt. Life Sci J. 2012;9(1):348-53.

Lee LK, Chen PC, Lee KK, Kaur J. Menstruation among adolescent girls in Malaysia: a cross-sectional school survey. Singapore medical journal. 2006 Oct;47(10):869-74.

Cakir M, Mungan I, Karakas T, Girisken I, Okten A. Menstrual pattern and common menstrual disorders among university students in Turkey. Pediatrics International. 2007 Dec 1;49(6):938-42.

Ohde S, Tokuda Y, Takahashi O, Yanai H, Hinohara S, Fukui T. Dysmenorrhea among Japanese women. International Journal of Gynecology & Obstetrics. 2008 Jan 1;100(1):13-7.

Babu GR, Sharma P. Problems related to menstruation amongst adolescent girls. Indian journal of pediatrics. 2010 Feb 1;77(2):218-9.

Danforth DN. Danforth's obstetrics and gynecology. Lippincott Williams & Wilkins; 2008.

Modaghegh MH, Shahabian M, Esmaeili HA, Rajbai O, Hosseinzadeh H. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine. 2008 Dec 31;15(12):1032-7.

Negbi M, editor. Saffron: Crocus Sativus L. CRC Press; 2003 Sep 2.

Shafieian Sh. The effect of Iranian medicine on primary dysmenorrhea and useful formulation;Pharmacology Doctorate Thesis; No: 797, Isfahan medical University 1983.

Shojaii A, Abdollahi Fard M. Review of pharmacological properties and chemical constituents of Pimpinella anisum. ISRN pharmaceutics. 2012 Jul 16;2012.

Nahidi F, Kariman N, Simbar M, Mojab F. The study on the effects of Pimpinella anisum on relief and recurrence of menopausal hot flashes. Iranian journal of pharmaceutical research: IJPR. 2012;11(4):1079.

Simbar M, Shadipour M, Salamzadeh J, Ramezani-Tehrani F, Nasiri N. The combination of “Pimpinella anisum, Apium graveolens and Crocus sativus (PAC)” is more effective than “mefenamic acid” on postpartum after-pain. Journal of herbal medicine. 2015 Mar 31;5(1):20-5.

Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC pharmacology. 2002 Mar 15;2(1):7.


  • There are currently no refbacks.

Creative Commons Attribution-NonCommercial 3.0

This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.