Comparison of the Effects of Crocus Sativus and Mefenamic Acid on Primary Dysmenorrhea
AbstractBackground: In previous studies, extract of 3 herbs, celery, fenugreek and saffron was effective on primary dysmenorrhea. However, the health effects of saffron alone on primary dysmenorrhea have not been yet studied. The aim of this double blind, single center clinical trial is to examine the effects of saffron on primary dysmenorrhea pain in women aged 18-27 years old.Methods: One hundred eighty patients were randomly divided into three groups. Group 1 received saffron capsules three times per day for three days of menstrual period for three consecutive menstrual cycles. Group 2 received mefenamic acid, and group 3 has received identical placebo. Visual Analogue Scale (VAS) has been recorded at baseline and after each menstrual period.Results: In saffron group VAS was reduced from 6.8 to 3.6, 3.4, and 3 in 3 consecutive months. This effect was significantly greater than mefenamic acid and placebo (P:0.0001).Conclusions: It was found that the effect of saffron in reducing pain is more than mefenamic acid and far more than placebo.
Khodakrami N, Moatar F, Ghahiri A. The effect of an Iranian herbal drug on primary dysmenorrhoea-A clinical control trial. OfogheDanesh 200815;14(2):11–19.
Iacovides S, Avidon I, Baker FC. What we knowabout primary dysmenorrhea today: a critical review. Hum Reprod Update
Latthe PM, Champaneria R, Khan KS. Dysmenorrhoea. BMJ Clin Evid2011;2011:0813.
Osayande AS, Mehulic S. Diagnosis and initial management of dysmenorrhea. Am Fam Physician 2014;89(5):341-6.
Ju H, Jones M, Mishra G. The prevalence and risk factors of dysmenorrhea.Epidemiol Rev 2014;36:104-13.
Chen CX, Kwekkeboom KL, Ward SE. Self-report pain and symptom measures for primary dysmenorrhoea: a critical review. Eur J Pain 2015;19(3):377-91.
De Sanctis V, Soliman A, Bernasconi S, et al. Primary Dysmenorrhea in Adolescents: Prevalence, Impact and Recent Knowledge. Pediatr Endocrinol Rev 2015;13(2):512-20.
Gagua T, Tkeshelashvili B, Gagua D. Primary dysmenorreah-leading problem of adolescent gynecology (review). Georgian Med News 2012;(207):7-14.
Bernardi M, Lazzeri L, Perelli F, Reis FM, Petraglia F.Dysmenorrhea and related disorders. F1000Res 2017;6:1645.
Modaghegh M, Shahabian M, Esmaeili H, Rajbai O. Safety evaluation of saffron (Crocus sativus) tablets in healthy volunteers. Phytomedicine2008 ;15(12):1032-7.
Carmona M, Zalacain A, Ma Sánchez A, Novella JL, Alonso GL, Crocetin Esters. Picrocrocin and Its Related Compounds Present in Crocus sativus Stigmas and Gardenia jasminoides Fruits. Tentative Identification of SevenNew Compounds by LC-ESI-MS. J Agric Food Chem 2006;54 (3):973-9.
Mirabi P, Alamolhoda SH, Esmaeilzadeh S, Mojab F. Effect of medicinal herbs on primary dysmenorrhoea- a systematic review. Iran J Pharm Res 2014;13(3):757-67
Burnett M, Lemyre M. No. 345-Primary Dysmenorrhea Consensus Guideline. J Obstet Gynaecol Can 2017;39(7):585-595.
Mirabi P, Mojab F. M203 Effects of Stachys Lavandulifolia on the Severityand Systemic Manifestations of Dysmenorrhea. Int J Gynecol Obstet 2012;119:S598.
Simbar M, Shadipour M, Salamzadeh J, Ramezani-Tehrani F, Nasiri N. Thecombination of “Pimpinella anisum, Apium graveolens and Crocus sativus (PAC)” is more effective than “mefenamic acid” on postpartum after-pain.Journal of Herbal Medicine 2015;5(1):20-25.
Hosseinzadeh H, Younesi HM. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMCPharmacol 2002;2:7.