Journal of Pharmaceutical Care 2017. 5(1-2):11-15.

Effect of Selenium Supplementation on CRP Levels and Incidence of Delirium in Critically Ill Patients
Babak Alikiaii, Sarah Mousavi, Seyed Taghi Hashemi, Mehran Abdollahi

Abstract


Abstract:
Context:
Selenium (Se) as an essential micronutrient with antioxidant and anti-inflammatory effects plays a primary role in human immune system and there are some evidences for its impact in reducing plasma levels of inflammatory factors on one hand and also their role in increased incidence of delirium on the other hand.
Aims:
The aim of his study is evaluation of the effect selenium on CRP plasma levels and incidence of delirium.
Settings and Design:
In a clinical trial included 100 patients admitted to the ICU of the Al-Zahra hospital in Isfahan (50 patients in the selenium group and 50 patients in the control group).
Methods and Material:
The plasma levels of C-reactive protein and incidence of delirium examined within 5 days and then compared.
Statistical analysis used:
The collected data were analysed using SPSS ver.23 (version 23, SPSS Inc., Chicago, IL).
Results:
During 5 days of hospitalization, 16 patients in the selenium group and 26 patients in the control group developed delirium in this term statistically there was no significant differences between the two groups (P=0.068).
During 5 days of hospitalization, plasma levels of CRPin the selenium group (mean = 11.1±2.20) significantly, was significantly lower than plasma levels of activated protein C in control group (mean= 16.75±1.65) (P<0.0001).
Conclusions:
Administering selenium lead to a decrease in plasma levels of CRP but administering selenium caused no significant changes in the incidence of delirium.

 

 


Keywords


Selenium (Se); C-reactive protein ; Delirium

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