Paroxetine Induced Akathisia: Necessity for Rational Use

  • Maryam Mousavi Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran
  • Padideh Ghaeli Faculty of Pharmacy and Roozbeh Psychiatric Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Fanak Fahimi Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Keywords: Paroxetine, Akathisia, Selective Serotonin Reuptake Inhibitor


Rare cases of akathisia have been reported with paroxetine in the literature. However, accurate diagnosis for early treatment is important since untreated akathisia can result in poor patients compliance, treatment failure, aggressive or suicidal acts.

We present a case of a 25-year- old female patient, suffering from akathisia, who was treated with paroxetine and olanzapine due to hypomania and general anxiety disorder. Our finding shows that side effects like akathisia could be addressed by the timing of the peak level of paroxetine. Thus, shifting the time of paroxetine consumption to reach its peak level at the sleeping period could be a rational approach for many patients.  More research is required to confirm that the observation of this case report was not accidental. 


benjamin James sadock,Virginia Alcott Sadock, Pedro Ruiz,Comprehensive textbook of psychiatry,In Sussman N, Selesctive serotonine reuptake inhibitors10th ed.2017 .p8060-8104

Koliscak LP, Makela EH,Selective serotonin reuptake inhibitor-induced akathisia. J Am Pharm Assoc (2003). 2009 Mar-Apr;49(2):e28-36; quiz e37-8. doi: 10.1331/JAPhA.2009.08083. Eur Psychiatq 1998 ; 13 : 109-I 1

THOMAS R. E. BARNES.A Rating Scale for Drug-Induced AkathisiaBr J Psy-chiatry, 154 (1989), pp. 672-676

Lipinski JF, Jr, Mallya G, Zimmerman P, Pope HG, Jr (1989): Fluoxetine-induced akathisia: Clinical and theoretical implications. J Clin Psychiatry 50:339-342.

Naranjo CA, Busto U, Sellers EM, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981; 30: 239-245.

Adler LA, Angrist B. Paroxetine and akathisia. Biol Psychiatry. 1995;37:336-337.

Baldassano CF, Truman CJ, Nierenberg A, Ghaemi SN, Sachs GSAkathisia: a review and case report following paroxetine treatment. Compr Psychiatry. 1996 Mar-Apr;37(2):122-4.

Olivera AA, A case of paroxetine-induced akathisia.Biol Psychiatry, 39 (1996), pp. 909-910

Bonnet-Brilhault F, Thibaut F, Leprieur A, Petit M.A case of paroxetine-induced akathisia and a review of SSRI-induced akathisia. Eur Psychiatry. 1998;13(2):109-11. doi: 10.1016/S0924-9338(98)80029-1.

How to Cite
Mousavi M, Ghaeli P, Fahimi F. Paroxetine Induced Akathisia: Necessity for Rational Use. J Pharm Care. 6(3-4):79-80.
Case Report(s)