The Effect of Selenium Serum Levels on Oral Mucositis Frequency and Severity in Patients with Head and Neck Radiation

  • Elahe Laali Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences
  • Soheila Manifar Department of Oral and Dental Disease, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran Tehran Province, Tehran, N Kargar
  • Ali Kazemian Department of Radiation-Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran, Tehran Province, Tehran, Doktor Qarib
  • Zahra Jahangard-Rafsanjani Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences
  • Kheirollah Gholami Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences
Keywords: Selenium, Head and Neck cancer, Oral Mucositis

Abstract

Background: Scientists show the cytoprotective effect of selenium and its important role in redox regulation and antioxidant functions. In this study, we aimed to investigate whether there is a difference between selenium levels before and after radiotherapy (RT) and the effects of serum selenium levels on RT-related oral mucositis (OM), in patients undergoing RT for head and neck cancer. Methods:             This prospective study includes 42 head and neck cancer patients treated by external beam radiotherapy at the Cancer Institution of Imam Khomeini Hospital, Tehran University of Medical Sciences. Plasma selenium concentrations were determined before and after RT. The grade of OM was evaluated weekly by the WHO oral toxicity scale.  Results: The mean patient age was 54.74 (range=18-81) years. For most of the patients, the histopathological diagnosis of cancer was squamous cell carcinoma (n=28 (66.7%)).  There was no significant difference in serum Se levels before and after RT (85.38±30.63 before radiation and 90.32±33.26 after radiation, p-value >0.05). ). Moreover, there was no significant difference between levels of Se after RT in patients who developed severe OM and who did not. Conclusion: In our study, we couldn’t find any significant difference in the levels of selenium before and after RT and also there was no association between Se levels and OM developing.

Author Biographies

Elahe Laali, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences
Board of clinical pharmacy, Tehran University of Medical Sciences
Soheila Manifar, Department of Oral and Dental Disease, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran Tehran Province, Tehran, N Kargar
Assistant Professor of Oral Health and Community Dentistry, Tehran University of Medical Sciences
Ali Kazemian, Department of Radiation-Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran, Tehran Province, Tehran, Doktor Qarib
Assistant Professor of Radiotherapy, Tehran University of Medical Sciences 
Zahra Jahangard-Rafsanjani, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences
Assistant Professor of Clinical Pharmacy, Tehran University of Medical Sciences
Kheirollah Gholami, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences
Professor of Clinical Pharmacy, Tehran University of Medical Sciences  affiliation number Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran, Karim Khane Zand Avenue, Hafte-Tir Square, Tehran

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Published
2019-07-16
How to Cite
1.
Laali E, Manifar S, Kazemian A, Jahangard-Rafsanjani Z, Gholami K. The Effect of Selenium Serum Levels on Oral Mucositis Frequency and Severity in Patients with Head and Neck Radiation. J Pharm Care. 6(3-4):39-43.
Section
Original Article(s)