Relationship between Parathyroid Hormone Level and Early Remodeling Heart Failure after Acute Myocardial Infarction

  • Zohreh Firouzi
  • Saeideh Mahdizadeh Sajjadieh
  • Maryam Mousavi
  • Zahra Erfanian
  • Maryam Zarif
Keywords: Myocardial infarction, Post MI event, Parathyroid hormone (PTH), Hyperparathyroidism, Vitamin D


Background: Previous studies have indicated that parathyroid hormone (PTH) has been linked to post-myocardial infarction (MI) development. The aim of this cross-sectional study was to evaluate the relationship between PTH level and heart failure due to post-infarction remodeling during the first 72 hours of hospitalization.

Method: 70 patients with a diagnosis of acute MI (age ≥18 years, 22 females and 48 males) were enrolled. Patients were admitted to the Imam Raza Educational, Research and Treatment Center, Mashhad University of Medical Sciences, Iran between July 2014 to September 2015. First blood samples were taken from all patients during the first 24 hours of admission to the hospital. The second samples were taken after 72 hours.

Results: Based on our findings, during the first 72 hours, the PTH level significantly increased in patients with Post-Myocardial Infarction Heart Failure. We also measured vitamin D level. Eighty- six percent of the subjects of the study had an inappropriate vitamin D level at the time of admission. Mean levels of vitamin D and PTH increased compared with the baselines (95% CI, 0.15 to 10.03, P = 0.044), (95% CI, 6.5 to 24.8, P = 0.001) respectively.

Conclusion: During the first 72 hours, the PTH level significantly increased in patients with heart failure due to post- infarction remodeling. Among these patients, PTH excess was associated with Post-Myocardial Infarction Heart Failure. Acute elevations of serum PTH levels increased early remodeling heart failure after MI. Serum vitamin D status was independent of high serum PTH level.


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How to Cite
Firouzi Z, Mahdizadeh Sajjadieh S, Mousavi M, Erfanian Z, Zarif M. Relationship between Parathyroid Hormone Level and Early Remodeling Heart Failure after Acute Myocardial Infarction. J Pharm Care. 8(1):11-15.
Original Article(s)