The Effect of Selenium Serum Levels on Oral Mucositis Frequency and Severity in Patients with Head and Neck Radiation
,
Abstract
Background: Radiotherapy as an important treatment modality in head and neck cancer diminishes reactive oxygen system which causes damages to the normal cell/tissue function and cell cycle regulation. Selenium involve in both antioxidant and anti-inflammatory systems. In this study, we aimed to investigate whether there is a difference between selenium levels before and after radiotherapy and the effects of serum selenium levels on radiotherapy oral mucositis (OM) patients undergoing radiation for head and neck cancer.
Methods:This prospective study includes 42 head and neck cancer patients treated by external beam radiotherapy at the Cancer Institution of Imam Khomeini Hospital, Tehran University of Medical Sciences. Plasma selenium concentrations were determined before and after RT. The grade of OM was evaluated weekly by the WHO oral toxicity scale.
Results: The mean patient age was 54.74 (range=18-81) years. For most of the patients, the histopathological diagnosis of cancer was squamous cell carcinoma (n=28 (66.7%)). There was no significant difference in serum Se levels before and after RT (85.38±30.63 before radiation and 90.32±33.26 after radiation, p-value >0.05). ). Moreover, there was no significant difference between levels of Se after RT in patients who developed severe OM and who did not.
Conclusion: In our study, we couldn’t find any significant difference in the levels of Selenium before and after radiotherapy and also there was no association between Selenium levels and oral mucositis developing.
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2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a cancer journal for clinicians. 2011 Mar-Apr;61(2):69-90. PubMed PMID: 21296855. Epub 2011/02/08. eng.
3. Silverman S. Oral Cancer. Hamilton, Ontario, Canada: American Cancer Society, BC Decker. Inc; 1998.
4. Ahn J, Ambrosone CB, Kanetsky PA, Tian C, Lehman TA, Kropp S, et al. Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer. Clinical cancer research. 2006;12(23):7063-70.
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6. Sonis ST. A biological approach to mucositis. J Support Oncol. 2004;2(1):21-32.
7. Lalla RV, Schubert MM, Bensadoun R-J, Keefe D. Anti-inflammatory agents in the management of alimentary mucositis. Supportive Care in Cancer. 2006;14(6):558-65.
8. Ryan-Harshman M, Aldoori W. The relevance of selenium to immunity, cancer, and infectious/inflammatory diseases. Canadian Journal of Dietetic Practice and Research. 2005;66(2):98-102.
9. Garberg P, Hogberg J. role of selenium-oxygen interactions in selenium metabolism. Ambio. 1986.
10. Martin-Romero FJ, Kryukov GV, Lobanov AV, Carlson BA, Lee BJ, Gladyshev VN, et al. Selenium metabolism in Drosophila selenoproteins, selenoprotein mRNA expression, fertility, and mortality. Journal of biological chemistry. 2001;276(32):29798-804.
11. Rayman MP. The importance of selenium to human health. The lancet. 2000;356(9225):233-41.
12. Arjmandi MK, Moslemi D, Zarrini AS, Gorji ME, Mosapour A, Haghhaghighi A, et al. Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease. Reports of Practical Oncology & Radiotherapy. 2016;21(3):141-8.
13. Fraunholz I, Eberlein K, Schopohl B, Bottcher HD, Rodel C. Selenium levels during the course of radiotherapy. No influence of irradiation on blood selenium concentration. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al]. 2008 Aug;184(8):411-5. PubMed PMID: 18956518. Epub 2008/10/30. eng.
14. Kasapović J, Pejić S, Todorović A, Stojiljković V, Radošević-Jelić L, Pajović SB. Antioxidant status in breast cancer patients of different ages after radiotherapy. Archives of Biological Sciences. 2009;61(1):23-8.
15. Pajović S, Pejić S, Kasapović J, Radojčić M, Borojević D N, Radošević-Jelić L. Role of superoxide dismutase in individualization of breast cancer radiation therapy protocols. Archive of Oncology. 2003;11(3):191-2.
16. Buentzel J, Micke O, Kisters K, Bruns F, Glatzel M, Schoenekaes K, et al. Selenium substitution during radiotherapy of solid tumours–laboratory data from two observation studies in gynaecological and head and neck cancer patients. Anticancer research. 2010;30(5):1783-6.
17. Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, et al. The effect of zinc sulfate in the prevention of high‐dose chemotherapy‐induced mucositis: a double‐blind, randomized, placebo‐controlled study. Hematological oncology. 2012;30(1):22-6.
18. Sonis ST. Oral mucositis. Anticancer Drugs. 2011;22(7):607-12.
19. Micke O, Schomburg L, Buentzel J, Kisters K, Muecke R. Selenium in oncology: from chemistry to clinics. Molecules. 2009;14(10):3975-88.
20. Tobe R, Mihara H. Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis. Biochimica et Biophysica Acta (BBA)-General Subjects. 2018.
21. Franca C, Nogueira C, Ramalho A, Carvalho A, Vieira S, Penna A. Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy. Annals of oncology. 2010;22(5):1109-12.
22. Yadav S, Gera A, Singh I, Chanda R. Serum selenium levels in patients with head and neck cancer. Journal of otolaryngology. 2002;31(4).
23. Eroglu C, Unal D, Cetin A, Orhan O, Sivgin S, OZTÜRK A. Effect of serum selenium levels on radiotherapy-related toxicity in patients undergoing radiotherapy for head and neck cancer. Anticancer research. 2012;32(8):3587-90.
24. Rodríguez-Caballero A, Torres-Lagares D, Robles-García M, Pachón-Ibáñez J, Gonzalez-Padilla D, Gutierrez-Perez J. Cancer treatment-induced oral mucositis: a critical review. International journal of oral and maxillofacial surgery. 2012;41(2):225-38.
25. Scully C, Sonis S, Diz P. Oral mucositis. Oral diseases. 2006;12(3):229-41.
26. Rodemann H, Hehr T, Bamberg M. Relevance of the radioprotective effect of sodium selenite. Medizinische Klinik (Munich, Germany: 1983). 1999;94:39-41.
27. Schleicher U, Lopez CC, Andreopoulos D, Handt S, Ammon J. Radioprotection of human endothelial cells by sodium selenite. Medizinische Klinik (Munich, Germany: 1983). 1999;94:35-8.
28. Persson-Moschos M, Alfthan G, Åkesson B. Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium. European journal of clinical nutrition. 1998;52(5):363.
29. Burk RF, Hill KE, Motley AK. Plasma selenium in specific and non‐specific forms. Biofactors. 2001;14(1‐4):107-14.
30. Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiology and Prevention Biomarkers. 2006;15(4):804-10.
2. Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA: a cancer journal for clinicians. 2011 Mar-Apr;61(2):69-90. PubMed PMID: 21296855. Epub 2011/02/08. eng.
3. Silverman S. Oral Cancer. Hamilton, Ontario, Canada: American Cancer Society, BC Decker. Inc; 1998.
4. Ahn J, Ambrosone CB, Kanetsky PA, Tian C, Lehman TA, Kropp S, et al. Polymorphisms in genes related to oxidative stress (CAT, MnSOD, MPO, and eNOS) and acute toxicities from radiation therapy following lumpectomy for breast cancer. Clinical cancer research. 2006;12(23):7063-70.
5. Trotti A, Bellm LA, Epstein JB, Frame D, Fuchs HJ, Gwede CK, et al. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiotherapy and oncology. 2003;66(3):253-62.
6. Sonis ST. A biological approach to mucositis. J Support Oncol. 2004;2(1):21-32.
7. Lalla RV, Schubert MM, Bensadoun R-J, Keefe D. Anti-inflammatory agents in the management of alimentary mucositis. Supportive Care in Cancer. 2006;14(6):558-65.
8. Ryan-Harshman M, Aldoori W. The relevance of selenium to immunity, cancer, and infectious/inflammatory diseases. Canadian Journal of Dietetic Practice and Research. 2005;66(2):98-102.
9. Garberg P, Hogberg J. role of selenium-oxygen interactions in selenium metabolism. Ambio. 1986.
10. Martin-Romero FJ, Kryukov GV, Lobanov AV, Carlson BA, Lee BJ, Gladyshev VN, et al. Selenium metabolism in Drosophila selenoproteins, selenoprotein mRNA expression, fertility, and mortality. Journal of biological chemistry. 2001;276(32):29798-804.
11. Rayman MP. The importance of selenium to human health. The lancet. 2000;356(9225):233-41.
12. Arjmandi MK, Moslemi D, Zarrini AS, Gorji ME, Mosapour A, Haghhaghighi A, et al. Pre and post radiotherapy serum oxidant/antioxidant status in breast cancer patients: Impact of age, BMI and clinical stage of the disease. Reports of Practical Oncology & Radiotherapy. 2016;21(3):141-8.
13. Fraunholz I, Eberlein K, Schopohl B, Bottcher HD, Rodel C. Selenium levels during the course of radiotherapy. No influence of irradiation on blood selenium concentration. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al]. 2008 Aug;184(8):411-5. PubMed PMID: 18956518. Epub 2008/10/30. eng.
14. Kasapović J, Pejić S, Todorović A, Stojiljković V, Radošević-Jelić L, Pajović SB. Antioxidant status in breast cancer patients of different ages after radiotherapy. Archives of Biological Sciences. 2009;61(1):23-8.
15. Pajović S, Pejić S, Kasapović J, Radojčić M, Borojević D N, Radošević-Jelić L. Role of superoxide dismutase in individualization of breast cancer radiation therapy protocols. Archive of Oncology. 2003;11(3):191-2.
16. Buentzel J, Micke O, Kisters K, Bruns F, Glatzel M, Schoenekaes K, et al. Selenium substitution during radiotherapy of solid tumours–laboratory data from two observation studies in gynaecological and head and neck cancer patients. Anticancer research. 2010;30(5):1783-6.
17. Mansouri A, Hadjibabaie M, Iravani M, Shamshiri AR, Hayatshahi A, Javadi MR, et al. The effect of zinc sulfate in the prevention of high‐dose chemotherapy‐induced mucositis: a double‐blind, randomized, placebo‐controlled study. Hematological oncology. 2012;30(1):22-6.
18. Sonis ST. Oral mucositis. Anticancer Drugs. 2011;22(7):607-12.
19. Micke O, Schomburg L, Buentzel J, Kisters K, Muecke R. Selenium in oncology: from chemistry to clinics. Molecules. 2009;14(10):3975-88.
20. Tobe R, Mihara H. Delivery of selenium to selenophosphate synthetase for selenoprotein biosynthesis. Biochimica et Biophysica Acta (BBA)-General Subjects. 2018.
21. Franca C, Nogueira C, Ramalho A, Carvalho A, Vieira S, Penna A. Serum levels of selenium in patients with breast cancer before and after treatment of external beam radiotherapy. Annals of oncology. 2010;22(5):1109-12.
22. Yadav S, Gera A, Singh I, Chanda R. Serum selenium levels in patients with head and neck cancer. Journal of otolaryngology. 2002;31(4).
23. Eroglu C, Unal D, Cetin A, Orhan O, Sivgin S, OZTÜRK A. Effect of serum selenium levels on radiotherapy-related toxicity in patients undergoing radiotherapy for head and neck cancer. Anticancer research. 2012;32(8):3587-90.
24. Rodríguez-Caballero A, Torres-Lagares D, Robles-García M, Pachón-Ibáñez J, Gonzalez-Padilla D, Gutierrez-Perez J. Cancer treatment-induced oral mucositis: a critical review. International journal of oral and maxillofacial surgery. 2012;41(2):225-38.
25. Scully C, Sonis S, Diz P. Oral mucositis. Oral diseases. 2006;12(3):229-41.
26. Rodemann H, Hehr T, Bamberg M. Relevance of the radioprotective effect of sodium selenite. Medizinische Klinik (Munich, Germany: 1983). 1999;94:39-41.
27. Schleicher U, Lopez CC, Andreopoulos D, Handt S, Ammon J. Radioprotection of human endothelial cells by sodium selenite. Medizinische Klinik (Munich, Germany: 1983). 1999;94:35-8.
28. Persson-Moschos M, Alfthan G, Åkesson B. Plasma selenoprotein P levels of healthy males in different selenium status after oral supplementation with different forms of selenium. European journal of clinical nutrition. 1998;52(5):363.
29. Burk RF, Hill KE, Motley AK. Plasma selenium in specific and non‐specific forms. Biofactors. 2001;14(1‐4):107-14.
30. Burk RF, Norsworthy BK, Hill KE, Motley AK, Byrne DW. Effects of chemical form of selenium on plasma biomarkers in a high-dose human supplementation trial. Cancer Epidemiology and Prevention Biomarkers. 2006;15(4):804-10.
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| Issue | Vol 6, No 3-4 (Summer 2018) | |
| Section | Original Article(s) | |
| Keywords | ||
| Selenium Head and Neck cancer Oral Mucositis | ||
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How to Cite
1.
Laali E, Manifar S, Kazemian A, Jahangard-Rafsanjani Z, Gholami K. The Effect of Selenium Serum Levels on Oral Mucositis Frequency and Severity in Patients with Head and Neck Radiation. J Pharm Care. 2019;6(3-4):39-43.
