Antimicrobial Resistance Pattern of Nosocomial Infections at a Referral Teaching Hospital

  • Rasool Soltani 1Department of Clinical Pharmacy and Pharmacy Practice, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Farzin Khorvash 2Department of Infectious Diseases, Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Fereshteh Pazandeh 3School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
Nosocomial Infections, Urinary Tract Infections, Pneumonia, Bloodstream Infections, Wound infections, Antimicrobial Resistance Pattern


Background: Due to high mortality rates of hospital infections, the choice of appropriate antibiotics to treat these infections is very important that requires determination of antibiotic resistance pattern in hospitals.

The aim of this study was to determine antimicrobial resistance patterns of common pathogens of nosocomial infections (pneumonia, UTI, bloodstream infection, wound infection) in hospitalized patients of Al-Zahra by disk diffusion method.

Methods: This cross-sectional study was conducted over a 6-month period. The pathogens isolated from biological samples of hospitalized patients with nosocomial pneumonia, UTI, bloodstream infection, or wound infection underwent antibiotic susceptibility testing by Kirby-Bauer method (disk diffusion test).

Results: Over the study period, 442 cases of infection were recorded. Pneumonia (n = 204, 46.2%) and UTI (n = 118, 26.7%) showed the most frequency followed by BSI (n = 71, 16.1%) and wound infection (n = 49, 11%). Acinetobacter baumannii was the most common pathogen of nosocomial pneumonia infection that showed the most susceptibility to colistin (100%). Escherichia coli, the most common pathogen of urinary tract infections, showed the highest sensitivity to colistin (100%). Staphylococcus epidermidis was the most common bloodstream infection pathogen that showed the most sensitivity to vancomycin (100%). Enterococcus spp., the most common pathogens of wound infection, had the most susceptibility to linezolid (100%).

Conclusion: Nosocomial infections in our hospital have high rate of resistance to antibiotics representing the importance of improvement in antibiotic use and infection control. The most common pathogens causing nosocomial pneumonia, UTI, BSI, and wound infection include Acinetobacter baumani, E. coli, Staphylococcus epidermidis, and Enterococcus spp, respectively. Colistin is the most effective antibiotic against Acinetobacter baumani and E. coli, while vancomycin and linezolid are the most effective antibiotics against Staphylococcus epidermidis, and Enterococcus spp, respectively. 


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How to Cite
Soltani R, Khorvash F, Pazandeh F. Antimicrobial Resistance Pattern of Nosocomial Infections at a Referral Teaching Hospital. J Pharm Care. 8(1):26-34.
Original Article(s)