Relationship between Parathyroid Hormone Level and Early Remodeling Heart Failure after Acute Myocardial Infarction

  • Zohreh Firouzi 1Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Saeideh Mahdizadeh Sajjadieh 2Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Maryam Mousavi 3Research Center for Rational Use of Drugs, Tehran University of Medical Sciences, Tehran, Iran.
  • Zahra Erfanian 4Department of Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Maryam Zarif 4Department of Cardiology, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Keywords:
Myocardial infarction, Post MI event, Parathyroid hormone (PTH), Hyperparathyroidism, Vitamin D

Abstract

Background: Previous studies have indicated that parathyroid hormone (PTH) has been linked to post-myocardial infarction (MI) development. The aim of this cross-sectional study was to evaluate the relationship between PTH level and heart failure due to post-infarction remodeling during the first 72 hours of hospitalization.

Method: 70 patients with a diagnosis of acute MI (age ≥18 years, 22 females and 48 males) were enrolled. Patients were admitted to the Imam Raza Educational, Research and Treatment Center, Mashhad University of Medical Sciences, Iran between July 2014 to September 2015. First blood samples were taken from all patients during the first 24 hours of admission to the hospital. The second samples were taken after 72 hours.

Results: Based on our findings, during the first 72 hours, the PTH level significantly increased in patients with Post-Myocardial Infarction Heart Failure. We also measured vitamin D level. Eighty- six percent of the subjects of the study had an inappropriate vitamin D level at the time of admission. Mean levels of vitamin D and PTH increased compared with the baselines (95% CI, 0.15 to 10.03, P = 0.044), (95% CI, 6.5 to 24.8, P = 0.001) respectively.

Conclusion: During the first 72 hours, the PTH level significantly increased in patients with heart failure due to post- infarction remodeling. Among these patients, PTH excess was associated with Post-Myocardial Infarction Heart Failure. Acute elevations of serum PTH levels increased early remodeling heart failure after MI. Serum vitamin D status was independent of high serum PTH level.

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Published
2020-03-24
How to Cite
1.
Firouzi Z, Mahdizadeh Sajjadieh S, Mousavi M, Erfanian Z, Zarif M. Relationship between Parathyroid Hormone Level and Early Remodeling Heart Failure after Acute Myocardial Infarction. J Pharm Care. 8(1):11-15.
Section
Original Article(s)