Is Intra-Cellular Magnesium Concentration Correlate with Morbidity and Mortality in Critically Ill Patients? A Cross-Sectional Study

  • Zinat Heidari Mail 1Department of Clinical Pharmacy, Faculty of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
  • Alireza Abdollahi 2Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
  • Hossein Khalili 3Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Keywords:
Intensive Care Units, Magnesium Deficiency, Intracellular Space, Critical Illness, Morbidity, Mortality

Abstract

Backgrounds: Hypomagnesemia is a common electrolyte disturbance among critically ill patient which is associated with increased morbidity and mortality. In this study, correlations between serum and intra-cellular magnesium concentrations at the time of intensive care unit (ICU) admission with ICU complications and mortality were evaluated.

Methods: This cross-sectional study included 70 consecutive adult patients admitted to the intensive care unit of a tertiary referral teaching hospital during a six-month period. Serum and intra-cellular magnesium levels were measured on admission. Clinical information, morbidity, and mortality were followed and recorded during ICU stay until discharge or death.

Results: On admission, 37.14% of patients suffered hypomagnesemia. Low intra-cellular magnesium level was observed in 44.28% of patients. Cardiovascular complications and mortality were significantly higher in patients with lower serum and intra-cellular magnesium levels when compared to patients with normal levels (P < 0.05). There was a significant correlation between serum magnesium level on ICU admission and Acute Physiology and Chronic Health Evaluation (APACHE II) score (r = ˗0.39, P < 0.001).

Conclusion: Particular attention should be reserved to possible prognostic and therapeutic consequences of magnesium depletion in critically ill patients. Magnesium deficiency was associated with a higher APACHE II score on admission, higher cardiovascular complications, and increased mortality.

Author Biographies

Alireza Abdollahi, 2Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

PhD in Pathology, Associated Professor, Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Hossein Khalili, 3Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

PhD in Clinical Pharmacy, Professor of Clinical Pharmacy, Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

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Published
2020-09-28
How to Cite
1.
Heidari Z, Abdollahi A, Khalili H. Is Intra-Cellular Magnesium Concentration Correlate with Morbidity and Mortality in Critically Ill Patients? A Cross-Sectional Study. J Pharm Care. 8(3):110-115.
Section
Original Article(s)