Herbal Medicine as Neuroprotective Potential Agent in Human and Animal Models: A Historical Overview
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Abstract
Neurodegenerative disorders could be a most important health issue within the 21st century. In the recent past; there has been a growing interest in medicinal plants. Chemical fruits and vegetables are said to decrease the possibility of many chief ailments, together with cardiovascular and cancer disorders as well as neurodegenerative ailments. Hence, who eat more fruits and vegetables may be less threaten for developing certain diseases caused by neurological dysfunction. The present review provides an overview of the about 14 most important plants used for neurological disorders and explores their neurological protection for the development of new pharmacological potential drugs. The data sources including the publications on Google Scholar, PubMed, and Science Direct. Publications searched with no particular time restriction in order to get a holistic and comprehensive view of the research done on this topic so far. Therefore, we present a systematic approach for herbal medicine as neuroprotective agent. From ancient time the herbal medicines are used to cure neurological symptoms. While the exact pharmacology of these herbs has not yet been set on, some of them have anti-inflammatory or antioxidant properties on different peripheral systems. The significant variety of medicinal plants makes it an essential source of healthy compounds compared to current therapeutic agents. In this review, the importance of phytochemicals for the function of neurological protection and other related disorders, in particular, the process mechanism and therapeutic prospective will be emphasize.
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2. Selvam A. Inventory of vegetable crude drug samples housed in botanical survey of India, Howrah. Pharmacognosy Reviews 2008;2(3):61-94.
3. Uriarte PI, Calvo M. Phytochemical study and evaluation of antioxidant, neuroprotective and acetylcholinesterase inhibitor activities of Galeopsis ladanum L. extracts. Pharmacognosy Magazine 2009;5(20):287-90.
4. Ghayour MB, Abdolmaleki A, Behnam-Rassouli M, Mahdavi-Shahri N, Moghimi A. Synergistic Effects of Acetyl-l-Carnitine and Adipose-Derived Stromal Cells on Improving Regenerative Capacity of Acellular Nerve Allograft in Sciatic Nerve Defect. J Pharmacol Exp Ther 2019;368(3):490-502.
5. Ghayour MB, Abdolmaleki A, Rassouli MB. Neuroprotective effect of Lovastatin on motor deficit induced by sciatic nerve crush in the rat. Eur J Pharmacol 2017;812:121-7.
6. Abdolmaleki A, Fereidoni M, Asgari A. Analgesic and Anti-Inflammatory Effects of Hydroalcoholic Extract of Salvia multicaulis on Male Rats. Sciences 2015;21(2):121-8.
7. Kumar V. Potential medicinal plants for CNS disorders: an overview. Phytother Res 2006;20(12):1023-35.
8. Abdolmaleki A, Moghimi A, Ghayour MB, Rassouli MB. Evaluation of neuroprotective, anticonvulsant, sedative and anxiolytic activity of citicoline in rats. Eur J Pharmacol 2016;789:275-9.
9. Houghton P, Raman A. Laboratory handbook for the fractionation of natural extracts. Springer Science & Business Media; 2012.
10. Capasso R, Izzo AA, Pinto L, Bifulco T, Vitobello C, Mascolo N. Phytotherapy and quality of herbal medicines. Fitoterapia 2000;71(Suppl 1):S58-S65.
11. Boskabady MH, Ghorani V, Alavinezhad A. Saffron, its main derivatives, and their effects on the respiratory systemSeries. In: Koocheki A and Khajeh-Hosseini M, editors. Saffron. Elsevier: Woodhead Publishing; 2020. p. 461-9.
12. Bathaie SZ, Mousavi SZ. New applications and mechanisms of action of saffron and its important ingredients. Crit Rev Food Sci Nutr 2010;50(8):761-86.
13. Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, Tsatsakis AM. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. Avicenna J Phytomed 2015;5(5):376-91.
14. Mokhtari-Zaer A, Khazdair MR, Boskabady MH. Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms. Avicenna J Phytomed 2015;5(5): 365-73.
15. Khazdair MR. The protective effects of Nigella sativa and its constituents on induced neurotoxicity. J Toxicol 2015;2015:841823.
16. Karimi E, Oskoueian E, Hendra R, Jaafar HZ. Evaluation of Crocus sativus L. stigma phenolic and flavonoid compounds and its antioxidant activity. Molecules 2010;15(9):6244-6256.
17. Tamaddonfard E, Farshid AA, Ahmadian E, Hamidhoseyni A. Crocin enhanced functional recovery after sciatic nerve crush injury in rats. Iran J Basic Med Sci 2013;16(1):83-90.
18. Saleem S, Ahmad M, Ahmad AS, et al. Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Med Food 2006;9(2):246-53.
19. Shati AA, Elsaid FG, Hafez EE. Biochemical and molecular aspects of aluminium chloride-induced neurotoxicity in mice and the protective role of Crocus sativus L. extraction and honey syrup. Neuroscience 2011;175:66-74.
20. Hajhashemi V, Ghannadi A, Jafarabadi H. Black cumin seed essential oil, as a potent analgesic and antiinflammatory drug. Phytother Res 2004;18(3):195-199.
21. El-Tahir KE, Bakeet DM. The black seed Nigella sativa Linnaeus-A mine for multi cures: a plea for urgent clinical evaluation of its volatile oil. Journal of Taibah University Medical Sciences 2006;1(1):1-19.
22. Kacem R, Meraihi Z. Effects of essential oil extracted from Nigella sativa (L.) seeds and its main components on human neutrophil elastase activity. Yakugaku Zasshi 2006;126(4):301-305.
23. Venkatachallam SKT, Pattekhan H, Divakar S, Kadimi US. Chemical composition of Nigella sativa L. seed extracts obtained by supercritical carbon dioxide. J Food Sci Technol 2010;47(6):598-605.
24. Burits M, Bucar F. Antioxidant activity of Nigella sativa essential oil. Phytother Res 2000;14(5):323-8.
25. Azzubaidi MS, Saxena AK, Talib NA, Ahmed QU, Dogarai BB. Protective effect of treatment with black cumin oil on spatial cognitive functions of rats that suffered global cerebrovascular hypoperfusion. Acta Neurobiol Exp (Wars) 2012;72(2):154-65.
26. Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR, Soukhtanloo M. Effects of the hydro-alcoholic extract of Nigella sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chin J Integr Med 2015;21(6):438-44.
27. Devi S, Gupta E, Sahu M, Mishra P. Proven Health Benefits and Uses of Coriander (Coriandrum sativum L.)Series. In: Mishra N, editor. Ethnopharmacological Investigation of Indian Spices. Kanpur: GI Global; 2020. p. 197-204.
28. Trifan A, Bostănaru AC, Luca SV, et al. Antifungal potential of pimpinella anisum, carum carvi and coriandrum sativum extracts. A comparative study with focus on the phenolic composition. Farmacia 2020;68(1):22-27.
29. Sahib NG, Anwar F, Gilani AH, Hamid AA, Saari N, Alkharfy KM. Coriander (Coriandrum sativum L.): a potential source of high-value components for functional foods and nutraceuticals-a review. Phytother Res 2013;27(10):1439‐56.
30. Petramfar P, Zarshenas MM, Moein M, Mohagheghzadeh A. Management of insomnia in traditional Persian medicine. Forsch Komplementmed 2014;21(2):119‐125.
31. Hosseinzadeh H, Madanifard M. Anticonvulsant effects of Coriandrum sativum L. seed extracts in mice. Archives of Iranian Medicine 2000;3(4):1-4.
32. Iranshahy M, Iranshahi M. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a review. J Ethnopharmacol 2011;134(1):1-10.
33. Khajeh M, Yamini Y, Bahramifar N, Sefidkon F, Pirmoradei MR. Comparison of essential oils compositions of Ferula assa-foetida obtained by supercritical carbon dioxide extraction and hydrodistillation methods. Food chemistry 2005;91(4):639-44.
34. Zia-Ul-Haq M, Shahid S A, Ahmad S, Qayum M, Khan I. Antioxidant potential of various parts of Ferula assafoetida L. J Med Plant Res 2012;6(16):3254-8.
35. Lee CL, Chiang LC, Cheng LH, et al. Influenza A (H1N1) antiviral and cytotoxic agents from Ferula assa-foetida. J Nat Prod 2009;72(9):1568-1572.
36. Bagheri SM, Rezvani ME, Vahidi AR, Esmaili M. Anticonvulsant effect of Ferula assa-foetida oleo gum resin on chemical and amygdala-kindled rats. N Am J Med Sci 2014;6(8):408-12.
37. Moghadam FH, Dehghan M, Zarepur E, et al. Oleo gum resin of Ferula assa-foetida L. ameliorates peripheral neuropathy in mice. J Ethnopharmacol 2014;154(1):183-9.
38. Zarmouh NO, Messeha SS, Elshami FM, Soliman KF. Natural products screening for the identification of selective monoamine oxidase-B inhibitors. European J Med Plants 2016;15(1):14802.
39. Vijayalakshmi P, Adiga S, Bhat P, Chaturvedi A, Bairy K, Kamath S. Evaluation of the effect of Ferula asafoetida Linn. gum extract on learning and memory in Wistar rats. Indian J Pharmacol 2012;44(1):82-7.
40. Kusindarta DL, Wihadmadyatami H, Haryanto A. Ocimum sanctum Linn. stimulate the expression of choline acetyltransferase on the human cerebral microvascular endothelial cells. Vet World 2016;9(12):1348-54.
41. Venuprasad M, Kumar KH, Khanum F. Neuroprotective effects of hydroalcoholic extract of Ocimum sanctum against H 2 O 2 induced neuronal cell damage in SH-SY5Y cells via its antioxidative defence mechanism. Neurochem Res 2013;38(10):2190-200.
42. Pan HY, Qu Y, Zhang JK, Kang TG, Dou DQ. Antioxidant activity of ginseng cultivated under mountainous forest with different growing years. J Ginseng Res 2013;37(3):355-60.
43. Kshirsagar AD, Mohite R, Aggrawal AS, Suralkar UR. Hepatoprotective medicinal plants of Ayurveda-A review. Asian Journal of Pharmaceutical and Clinical Research 2011;4(3):1-8.
44. Chen XC, Zhu YG, Zhu LA, et al. Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress. Eur J Pharmacol 2003;473(1):1-7.
45. Teltumbde A, Wahurwagh A, Lonare M, Nesari MT. Effect of Yashtimadhu (Glycyrrhiza Glabra) on intelligence and memory function in male adolescents. Scholars Journal of Applied Medical Sciences 2013;1(2):90-95.
46. Yu XQ, Xue CC, Zhou ZW, et al. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci 2008;82(1-2):68-78.
47. Muralidharan P, Balamurugan G, Babu V. Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract. Bangladesh Journal of Pharmacology 2009;4(1):60-64.
48. Geng Y, Li C, Liu J, et al. Beta-asarone improves cognitive function by suppressing neuronal apoptosis in the beta-amyloid hippocampus injection rats. Biol Pharm Bull 2010;33(5):836-43.
49. Patel V, Jivani N, Patel S. Medicinal plants with potential nootropic activity: a review. Research Journal of Pharmaceutical, Biological and Chemical Sciences 2014;5(1):1-11.
50. Paterna J-C, Leng A, Weber E, Feldon J, Büeler H. DJ-1 and Parkin modulate dopamine-dependent behavior and inhibit MPTP-induced nigral dopamine neuron loss in mice. Mol Ther 2007;15(4):698-704.
51. Bayan L, Koulivand PH, Gorji A. Garlic: a review of potential therapeutic effects. Avicenna J Phytomed 2014;4(1):1-14.
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| Files | ||
| Issue | Vol 8, No 2 (Spring 2020) | |
| Section | Review Article(s) | |
| DOI | https://doi.org/10.18502/jpc.v8i2.3832 | |
| Keywords | ||
| Neurodegenerative Diseases; Herbal Medicine Nervous System Plants Medicinal | ||
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
How to Cite
1.
Abdolmaleki A, Akram M, Muddasar Saeed M, Asadi A, Kajkolah M. Herbal Medicine as Neuroprotective Potential Agent in Human and Animal Models: A Historical Overview. J Pharm Care. 2020;8(2):75-82.
