Citalopram induced nightmare in an elderly man: a case-report

  • Effat Davoudi-Monfared Department of Clinical Pharmacy, 13-Aban Drug and Poison Information Center, Tehran University of Medical Sciences, Tehran, Iran
  • Hamidreza Taghvaye Masoumi Mail Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Enqelab Square, Tehran, Iran
citalopram, nightmare, case-report


An 80-year-old man developed nightmares while using citalopram for mild depression. During the first two weeks of treatment with citalopram (10 mg daily), he didn’t experience any adverse reactions. After two weeks, he developed nightmaresand vivid dreams that were repeated every night and awakened him in midnight. Although the signs of depression were relatively disappeared, the patient was anxious during the day due to nightmares and nocturnal awakenings. We, as pharmacists, consulted his family to decrease the dose to 10 mg every other day, and tell his physician as soon as possible. He decreased the doses and after two weeks the frequencyof nightmares was less. More follow-up revealed that the nightmares were totally disappeared one month after drug withdrawal. A Naranjo assessment score of 7 was obtained, showing a probable relationship between theadverse reaction and suspected drug.


American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition. 5th ed. Washington, DC, 2013.

Tribl GG, Wetter TC, Schredl M. Dreaming under antidepressants: A systematic review on evidence in depressive patients and healthy volunteers. Sleep Med Rev 2013;17:133-142.

Zajecka J,Tracy KA, Mitchell S. Discontinuation symptoms after treatment with Serotonin Reuptake Inhibitors: a literature review.. Journal of clinical Psychiatry1997;58(7): 291-297.

Pace-Schott EF, Gresh T, Silvestri R, Stickgold R, Salzman C, Habson JA. SSRI Treatment suppresses dream recall frequency but increases subjective dream intensity in normal subjects. J. Sleep Res 2001;10:129-142.

Bezchlibnyk-Butler K, Aleksic I, Kennedy SH. Citalopram-a review of pharmacological and clinical effects. J Psychiatry Neurosci 2000;25(3):241-254

Arora G, Sandhu G, Fleser C. Citalopram and Nightmares. J Neuropsychiatry Clin Neurosci 2012;24(2): E43

Kobayashi T, Yamauchi M. A case of serial nightmares and oneiroid state under paroxetine for senile depression. Psychogeriatr 2012; 12: 54–57ps

How to Cite
Davoudi-Monfared E, Taghvaye Masoumi H. Citalopram induced nightmare in an elderly man: a case-report. J Pharm Care. 3(3-4):77-78.
Case Report(s)