Review Article

Vitamin D Utilization May Improve Military Performance: A Mini-Review

Abstract

Studies from different regions of the world show that vitamin D deficiency is a common problem across the globe, even in military personnel. Risk factors of this deficiency includes elderly and female population, higher geographical latitudes, winter season, darker skins, low sunlight exposure, diet, and lack of vitamin D supplementation /fortification, although the deficiency in areas with higher sun exposure also has been documented. 
We reviewed some of the clinical trials and observations regarding vitamin D deficiency and supplementation. It has been shown that vitamin D deficiency is associated with more acute respiratory tract infections and acute pharyngitis resulting in more days off from training, more bone stress fractures, poor physical performance, and increased risk for suicide.
Clinical trials that utilized supplemental vitamin D shows decreased incidence of stress fractures in female navy recruits, lower incidence of influenza A and lower risk of acute respiratory tract infections, and improved bone density during initial military training, although one systematic review found conflicting data in supplementation with vitamin D for the prevention of acute respiratory infection.
These data opens a window for supplementation with vitamin D in populated military bases to decrease rate of respiratory infection and to minimize stress fractures for better performances; doses used for these purposes ranges from 300 to 1200 IU per day. Further clinical trials of vitamin D supplementation or dietary fortification for these military purposes should be conducted to determine the optimum dose and duration.

ROSEN, C. J., ADAMS, J. S., BIKLE, D. D., et al., The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement. Endocrine Reviews, 2012. 3(33): 456-492.

MILLER, J. W., HARVEY, D. J., BECKETT, L. A., et al., Vitamin D Status and Rates of Cognitive Decline in a Multiethnic Cohort of Older Adults. JAMA Neurol., 2015. 72(11): 1295-1303.

RUOHOLA, J.-P., LAAKSI, I., YLIKOMI, T., et al., Association Between Serum 25(OH)D Concentrations and Bone Stress Fractures in Finnish Young Men. JOURNAL OF BONE AND MINERAL RESEARCH, 2006. 21(9).

LAAKSI, I., RUOHOLA, J.-P., TUOHIMAA, P., et al., An association of serum vitamin D concentrations <40 nmol/L with acute respiratory tract infection in young Finnish men. Am J Clin Nutr, 2007. 86:714 -7.

SCIENCE, M., MAGUIRE, J. L., RUSSELL, M. L., SMIEJA, M., WALTER, S. D., and LOEB, M., Low Serum 25-hydroxyvitamin D Level and Risk of Upper Respiratory Tract Infection in Children and Adolescents. Clinical Infectious Diseases, 2013. 57(3): 392-397.

URASHIMA, M., SEGAWA, T., OKAZAKI, M., KURIHARA, M., WADA, Y., and IDA, H., Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr, 2010. 91: 1255-60.

MILANESCHI, Y., HOOGENDIJK, W., LIPS, P., et al., The association between low vitamin D and depressive disorders. Molecular Psychiatry, 2014. 19: 444-451.

MILLER, J. R., DUNN, K. W., JR, L. J. C., PATEL, R. D., and SWANSON, B. A., Association of Vitamin D With Stress Fractures: A Retrospective Cohort Study. The Journal of Foot & Ankle Surgery, 2016. 55: 117-120.

DONG, J.-Y., ZHANG, W., CHEN, J. J., ZHANG, Z.-L., HAN, S.-F., and QIN, L.-Q., Vitamin D Intake and Risk of Type 1 Diabetes: A Meta-Analysis of Observational Studies. Nutrients, 2013. 5(9): 3551-3562.

YUEN, A. W. C. and JABLONSKI, N. G., Vitamin D: In the evolution of human skin colour. Medical Hypotheses, 2010. 74: 39-44.

MITHAL, A., WAHL, D. A., BONJOUR, J.-P., et al., Global vitamin D status and determinants of hypovitaminosis D. Osteoporosis International, 2009. 20(11): 1807-1820.

BINKLEY, N., NOVOTNY, R., KRUEGER, D., et al., Low Vitamin D Status despite Abundant Sun Exposure. The Journal of Clinical Endocrinology & Metabolism, 2007. 92(6): 2130-2135.

HESHMAT, R., MOHAMMAD, K., MAJDZADEH, S., et al., Vitamin D Deficiency in Iran: A Multi-center Study among Different Urban Areas. Iranian J Publ Health, 2008. 1: 72-78.

HOLICK, M. F. and CHEN, T. C., Vitamin D deficiency: a worldwide problem with health consequences. Am J Clin Nutr, 2008(87(suppl)): 1080S- 6S.

CAMARGO, C. A., GANMAA, D., FRAZIER, A. L., et al., Randomized Trial of Vitamin D Supplementation and Risk of Acute Respiratory Infection in Mongolia. PEDIATRICS, 2012. 130(3): e561-7.

NEYESTANI, T. R., HAJIFARAJI, M., OMIDVAR, N., et al., High prevalence of vitamin D deficiency in school-age children in Tehran, 2008: a red alert. Public Health Nutrition, 2011. 15(2): 324-330.

SABETTA, J. R., DEPETRILLO, P., CIPRIANI, R. J., SMARDIN, J., BURNS, L. A., and LANDRY, M. L., Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLoS ONE, 2010. 5(6): e11088.

BISCHOFF-FERRARI, H. A., Optimal Serum 25-Hydroxyvitamin D Levels for Multiple Health Outcomes, in Sunlight, Vitamin D and Skin Cancer. 2014, Springer New York. p. 500-525.

ANDERSEN, N. E., KARL, J. P., CABLE, S. J., et al., Vitamin D status in female military personnel during combat training. Journal of the International Society of Sports Nutrition, 2010. 7: 38.

LUTZ, L. J., KARL, J. P., ROOD, J. C., et al., Vitamin D status, dietary intake, and bone turnover in female Soldiers during military training: a longitudinal study. Journal of the International Society of Sports Nutrition, 2012. 9: 38.

ALAZZEH, A., COOPER, M. M., BAILEY, B., YOUSSEF, D. A., MANNING, T., and PEIRIS, A. N., Vitamin D Status and Monitoring in Female Veterans. Women & Health, 2015. 55(4): DOI:10.1080/03630242.2015.1022685.

WENTZ, L., BERRY-CABÁN, C., ELDRED, J., and WU, Q., Vitamin D Correlation with Testosterone Concentration in US Army Special Operations Personnel The FASEB Journal, 2015. 29(1Supplement): 733-5.

BAILEY, B. A., MANNING, T., and PEIRIS, A. N., Vitamin D Testing Patterns Among Six Veterans Medical Centers in the Southeastern United States: Links With Medical Costs. MILITARY MEDICINE, 2012. 177(1): 70-76.

SHERMAN, E. M. and SVEC, R. V., Barriers to Vitamin D Supplementation Among Military Physicians MILITARY MEDICINE, 2009. 174(3): 302-307.

FARRAR, M. D., WEBB, A. R., KIFT, R., et al., Efficacy of a dose range of simulated sunlight exposures in raising vitamin D status in South Asian adults: implications for targeted guidance on sun exposure. Am J Clin Nutr, 2013. 97: 1210-6.

CHAPUY, M.-C., PREZIOSI, P., MAAMER, M., et al., Prevalence of Vitamin D Insufficiency in an Adult Normal Population Osteoporosis International, 1997. 7(5): 439-443.

CHENA, T. C., CHIMEHA, F., LUA, Z., et al., Factors that influence the cutaneous synthesis and dietary sources of vitamin D. Archives of Biochemistry and Biophysics, 2007. 460(2): 213-217.

HORN, L. V. V., BAUSERMANN, R., AFFENITO, S., et al., Ethnic differences in food sources of vitamin D in adolescent American girls: the National Heart, Lung, and Blood Institute Growth and Health Study Nutrition Research, 2011. 31(8): 579-585.

GANNAGÉ-YARED, CHEMALI, SFEIR, MAALOUF, and HALABY, Dietary Calcium and Vitamin D Intake in an Adult Middle Eastern Population: Food Sources and Relation to Lifestyle and PTH. International Journal for Vitamin and Nutrition Research, 2015. 75: 281-289.

BROWN, J., IGNATIUS, A., AMLING, M., and BARVENCIK, F., New perspectives on vitamin D sources in Germany based on a novel mathematical bottom-up model of 25(OH)D serum concentrations. European Journal of Nutrition, 2013. 52(7): 1733-1742.

BROT, C., VESTERGAARD, P., KOLTHOFF, N., GRAM, J., HERMANN, A. P., and ̆RENSEN, O. H. S., Vitamin D status and its adequacy in healthy Danish perimenopausal women: relationships to dietary intake, sun exposure and serum parathyroid hormone. British Journal of Nutrition, 2001. 86(Suppl. 1): S97-S103.

GERMAN, V., KOPTERIDES, P., POULIKAKOS, P., GIANNAKOS, G., and FALAGAS, M. E., Respiratory tract infections in a military recruit setting: A prospective cohort study. Journal of Infection and Public Health, 2008. 1: 101-104.

SEAH, S. G.-K., LIM, E. A.-S., KOK-YONG, S., et al., Viral agents responsible for febrile respiratory illnesses among military recruits training in tropical Singapore. Journal of Clinical Virology, 2010. 47: 289-292.

JOLLIFFE, D. A., GRIFFITHS, C. J., and MARTINEAU, A. R., Vitamin D in the prevention of acute respiratory infection: Systematic review of clinical studies. Journal of Steroid Biochemistry & Molecular Biology, 2013. 136: 321- 329.

MALONEY, S. R., ALMARINES, D., and GOOLKASIAN, P., Vitamin D Levels and Monospot Tests in Military Personnel with Acute Pharyngitis: A Retrospective Chart Review. PLoS ONE, 2014. 9(7): e101180.

JHUN, B. W., KIM, S. J., KIM, K., LEE, J. E., and HONG, D. J., Vitamin D Status in South Korean Military Personnel with Acute Eosinophilic Pneumonia: A Pilot Study. Tuberc Respir Dis, 2015. 78: 232-238.

LAAKSI, I., RUOHOLA, J.-P., MATTILA, V., AUVINEN, A., YLIKOMI, T., and PIHLAJAMAKI, H., Vitamin D Supplementation for the Prevention of Acute Respiratory Tract Infection: A Randomized, Double-Blinded Trial among Young Finnish Men. The Journal of Infectious Diseases, 2010. 202(5): 809-814.

COSMAN, F., RUFFING, J., ZION, M., et al., Determinants of stress fracture risk in United States Military Academy cadets. Bone, 2013. 55 359-366.

ASTUR, D. C., ZANATTA, F., ARLIANI, G. G., MORAES, E. R., POCHINI, A. D. C., and EJNISMAN, B., Stress fractures: definition, diagnosis and treatment. Rev Bras Ortop, 2016. 51(1): 3-10.

MILLER, J. R., DUNN, K. W., JR., L. J. C., PATEL, R. D., and SWANSON, B. A., Association of Vitamin D With Stress Fractures: A Retrospective Cohort Study. The Journal of Foot & Ankle Surgery, 2016. 55: 117-120.

REDZIC, M., LEWIS, R. M., and THOMAS, D. T., Relationship between 25-hydoxyvitamin D, muscle strength, and incidence of injury in healthy adults: a systematic review. NUTRITION RESEARCH, 2013. 33 251-258.

DAO, D., SODHI, S., TABASINEJAD, R., et al., Serum 25-Hydroxyvitamin D Levels and Stress Fractures in Military Personnel, A Systematic Review and Meta-analysis. Am J Sports Med, 2015. 43 (8 ): 2064-2072.

LAPPE, J., CULLEN, D., HAYNATZKI, G., RECKER, R., AHLF, R., and THOMPSON, K., Calcium and Vitamin D Supplementation Decreases Incidence of Stress Fractures in Female Navy Recruits. JOURNAL OF BONE AND MINERAL RESEARCH, 2008. 23(5).

GAFFNEY-STOMBERG, E., LUTZ, L. J., ROODB, J. C., et al., Calciumand vitamin D supplementationmaintains parathyroid hormone and improves bone density during initial military training: A randomized, double-blind, placebo controlled trial. Bone, 2014. 68: 46-56.

MUNGER, K. L., LEVIN, L. I., MASSA, J., HORST, R., ORBAN, T., and ASCHERIO, A., Preclinical Serum 25-Hydroxyvitamin D Levels and Risk of Type 1 Diabetes in a Cohort of US Military Personnel. American Journal of Epidemiology, 2013: doi: 10.1093/aje/kws243.

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IssueVol 4, No 1-2 (Spring 2016) QRcode
SectionReview Article(s)
Keywords
Cholecalciferol Military Hygiene Work Performance

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How to Cite
1.
Abrishami R, Najmeddin F. Vitamin D Utilization May Improve Military Performance: A Mini-Review. J Pharm Care. 2017;4(1-2):33-36.